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PB-22 and 5F-PB-22 were being the 1st artificial cannabinoids to incorporate a quinoline substructure and an ester linkage. These compounds are assumed to are synthesized While using the intention of constructing a artificial cannabinoid prodrug, which could improve absorption and confound detection. Ester bonds are very easily biodegradable via spontaneous or endogenous, nonspecific esterase hydrolysis, that has been normally Employed in medicinal chemistry to make ester prodrugs.

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